What is it about?
PDX-1 is an important transcription factor in the normal functioning of adult pancreatic beta cells. It also plays a significant role in the multiplication of beta cells and in the reduction of beta-cell death. Phytochemical naringin increases the expression of PDX-1 in diabetic rats and thereby ameliorates diabetes.
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Why is it important?
Naringin increases the expression of the functionally important transcription factor in beta-cell of diabetic rats.
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This page is a summary of: Naringin (4′,5,7-Trihydroxyflavanone 7-Rhamnoglucoside) Attenuates β-Cell Dysfunction in Diabetic Rats through Upregulation of PDX-1, Cells Tissues Organs, January 2018, Karger Publishers,
DOI: 10.1159/000496506.
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