The Correlation of Serum Brain Natriuretic Peptide and Interleukin-6 with Quality of Life Using Chronic Obstructive Pulmonary Disease Assessment Test

What is it about?

The aim of this study was to determine the levels of serum pro-brain natriuretic peptide (pro-BNP) and interleukin (IL)-6 in patients with stable chronic obstructive pulmonary disease (COPD) and to correlate these markers with health-related quality of life using the COPD assessment test

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Why is it important?

This study revealed that with increasing severity of obstruction in patients with stable chronic obstructive pulmonary disease (COPD), both IL-6 and pro-brain natriuretic peptide (pro-BNP) increased. Of equal importance, a significant positive correlation was observed between IL-6 and pro-BNP serum levels. This increase in inflammatory markers was associated with a reduced quality of life and the severity of hypoxia. These findings indicate that lowering IL-6 and pro-BNP could be useful in the management of COPD patients.