What is it about?
Natural killer cells (NK) contribute to innate immunity against malaria either by direct lysis of Plasmodium falciparum -infected red blood cells or through IFN-γ production . In this study we have demonstrated that the consequence of untreated HIV-1 infection was to significantly reduce NK cell IFN-γ production following exposure to Plasmodium falciparum -infected red blood cells.
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Why is it important?
In malaria intense regions, there is need to consider people living with HIV as being highly vulnerable to malaria and should therefore be offered prophylactic malaria treatment like in pregnant women and children .
Read the Original
This page is a summary of: The Effect of Antiretroviral Naïve HIV-1 Infection on the Ability of Natural Killer Cells to Produce IFN-γ upon Exposure to Plasmodium falciparum-Infected Erythrocytes, Biomedicine Hub, April 2017, Karger Publishers,
DOI: 10.1159/000467386.
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