Donor hemovigilance evaluated from 1.1 million donations

What is it about?

Reports on unexpected donor events (UEs) during preparatory plasmapheresis (PPP) are scarce, and rarely consider technical UEs. Methods: Defined local and systemic UEs were graded by severity; technical UEs were not graded. On January 1, 2008, E.B.P.S.-Logistics (EBPS) installed the UE module for plasma management software (PMS). Donor room physicians entered UEs daily into the PMS. Medical directors reviewed entries quarterly.

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Why is it important?

It's the lagrgest data base evaluated. The overall incidence was at 6.55% (1.4% local, 0.55% systemic, 4.6% technical UEs). The majority was found at the first donations. Non of the UE was severe. Most common UEs were repeated venipuncture, and broken-off collection due to venous access problems and small hematomas. Severe systemic UEs occurred at a rate of 36 per 100,000 PPPs. Technical UEs were common with PPP. UEs accompanied first and second donations significantly more frequently than for subsequent donations.

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