What is it about?
Dialysis dose is a key parameter. Often it is determined via a first blood sample before dialysis and a second blood sample after dialysis, both blood samples measured in a laboratory concerning urea concentration. Nowadays, automatic non-invasive online measurements are available, when the urea distribution volume is known. Urea distribution volume can be based on an anthropometric estimation or on multifrequency bioimpedance measurements.
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Why is it important?
In this international clinical trial 3 methods were applied in 1,076 hemodialysis patients, and it was shown that the method with the urea distribution volume based on multifrequency bioimpedance measurements is nearest to the conventional method. Anthropometric estimations (Watson formula) are often inaccurate and underestimate the delivered dialysis dose.
Perspectives
The delivered dialysis dose as a key performance indicator of dialysis quality should be monitored closely. With the automatic non-invasive online measurement this is easily possible: without delay, directly at the end of the treatment. Thus, dialysis dose can me measured at each treatment: without blood loss for the patient, without work load for the nurse, and without costs for the measurements.
Dr. Ralf G. Wojke
Fresenius Medical Care
Read the Original
This page is a summary of: Determination of Dialysis Dose: A Clinical Comparison of Methods, Blood Purification, January 2011, Karger Publishers,
DOI: 10.1159/000330340.
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