What is it about?
Eosinophils are attracted by SP and activated to enhanced mediator release and cytotoxic activity.
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Why is it important?
Substance P, a mediator of the pain nervous system, acts on human eosinophils by attracting them to increase their migration to the point where Substance P is released; this phenomenon is called the Tripel-Response that is a reflecting response of nervous to the immune system to increase inflammation
Perspectives
The importance of this manuscript is the description of a phenomenon that the vegetative nervous system has a role in enhancing the inflammation, e.g. in asthma bronchiale.
Professor Franz J Wiedermann
Dpt. of Anaesthesiology & Critical Care Medicine,Innsbruck Medical University
Read the Original
This page is a summary of: Induction of Normal Human Eosinophil Migration in vitro by Substance P, Acta Haematologica, January 1993, Karger Publishers,
DOI: 10.1159/000204527.
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