What is it about?
Renal function has an important bearing on plasma homocysteine levels. Plasma homocysteine is related to left ventricular hypertrophy (LVH). However, it remains unclear whether the association between plasma homocysteine levels and LVH is influenced by renal function. This study aimed to investigate relationships among left ventricular mass index (LVMI), plasma homocysteine levels and renal function in a population from southern China.
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Why is it important?
There existed an independent correlation between plasma homocysteine levels and LVMI in hypertensive patients with normal eGFR. Our study provided evidence for relationships among plasma homocysteine levels, LVH and renal function in a population from southern China.
Perspectives
Our research shows that there is a significant correlation between high levels of homocysteine and LVH before declining renal function, suggesting that early intervention of hyperhomocysteinemia before declining renal function may be beneficial to prevent LVH. Moreover, our result also indicates that the remaining renal function needs to be taken into account when explaining the relationship between homocysteine and other factors.
Lingyu Zhang
the First Affiliated Hospital of Fujian Medical University
Read the Original
This page is a summary of: Increased plasma homocysteine levels are associated with left ventricular hypertrophy in hypertensive patients with normal renal function., Kidney and Blood Pressure Research, March 2023, Karger Publishers,
DOI: 10.1159/000529903.
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