What is it about?

Complement activation is important in the pathogenesis of many different kidney diseases. We compared complement activation by measuring C5b-9 in the blood and kidney tissue of 37 patients. We found that soluble C5-b9 is a marker of recent complement activation as opposed to complement deposition in kidney tissue, which can build up over time.

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Why is it important?

With the emergence of therapeutic complement inhibitors, there is a need to identify patients with complement-driven inflammation. We hope that plasma sC5b-9 is a potentially useful tool in identifying patients and conditions with recent complement activation.

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This page is a summary of: Measurement of complement activation via plasma soluble C5b-9 comparison with terminal complement complex staining in a series of kidney biopsies, Kidney and Blood Pressure Research, March 2023, Karger Publishers, DOI: 10.1159/000529734.
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