What is it about?
In this paper, we found a marginal association of TNF-α-308 G/A with diabetic retinopathy (DR) risk in the overall analysis, and an enhanced association among the European population. Besides,for the TNF-α-238 G/A polymorphism, there was mild correlation in the entire group, which was strengthened among the Asian population. As a result, we proposed that -308 A and -238 A allele in TNF-α gene potentially increased DR risk and showed a discrepancy in different ethnicities.
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Why is it important?
Increasing evidence has indicated the promotion of TNF-α in the development of diabetic retinopathy (DR), and TNF-α gene variants may influence DR risk. However, the results remains conflicting. To comprehensively address this issue, we adopted the variants of TNF-α-308 G/A and -238 G/A, which had been studied most broadly, and performed the meta-analysis to evaluate the association of them with DR.
Perspectives
I hope results of the study can do a little bit to promote the progress of medical knowledge, which will make me feel very honored.
Wenna Gao
Peking University First Hospital
Read the Original
This page is a summary of: Association of tumor necrosis factor-alpha -308 G/A and -238 G/A polymorphism with diabetic retinopathy: a systematic review and updated meta-analysis., Ophthalmic Research, December 2020, Karger Publishers,
DOI: 10.1159/000513586.
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