What is it about?

Phytochemical naringin causes an increase in the production of FoxM1 transcription factor in the beta cells of the diabetic rat pancreas. FoxM1 is a factor expressed only in dividing cells. Its expression in the pancreatic beta cells of diabetic rats shows that naringin induces proliferation in the beta cells. The study reveals one of the possible mechanism by which naringin ameliorates diabetes.

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Why is it important?

Naringin induces the proliferation of pancreatic beta cells in diabetic rats.


Irrespective of the type of diabetes, the proliferation of pancreatic beta cells and their functional status deteriorates as the disease advances. Phytochemical naringin induces proliferation and helps in controlling diabetes.

Dr Manickam Subramanian
Chettinad Academy of Research and Education

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This page is a summary of: Naringin Ameliorates Streptozotocin-Induced Diabetes through Forkhead Box M1-Mediated Beta Cell Proliferation, Cells Tissues Organs, January 2018, Karger Publishers, DOI: 10.1159/000499480.
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