NOD2 Modulates Serotonin Transporter and Interacts with TLR2 and TLR4 in Intestinal Epithelial Cells

Elena Layunta, Eva Latorre, Raquel Forcén, Laura Grasa, Marta Castro, Maykel A. Arias, Ana I. Alcalde, José Emilio Mesonero
  • Cellular Physiology and Biochemistry, January 2018, Karger Publishers
  • DOI: 10.1159/000490218

Intestinal SERT Modulation by NOD2 Activation

What is it about?

NOD2 activation inhibits SERT activity in Caco-2/TC7 cells, mainly due to the decrement of SERT molecular expression, with RIP2/RICK being the intracellular pathway involved in this effect. This inhibitory effect on SERT would yield an increment of extracellular 5-HT availability, wich inhibits NOD2 expression. In addition, NOD2 showed interdependence with TLR2. Indeed, NOD2 expression significantly increased in both cells treated with TLR2 agonists and the intestinal tract of Tlr2-/- mice.

Why is it important?

It may be inferred from our data that NOD2 could play a role in intestinal pathophysiology not only through its inherent innate immune role but also due to its interaction with other receptors as TLR2 and the modulation of the intestinal serotonergic system decreasing SERT activity and expression.

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The following have contributed to this page: Jose Emilio Mesonero