What is it about?

Higher SLC6A4 mRNA expression in leukocytes in AD was associated with apathy regardless of SLC6A4 genotypes and methylation rates of the promoter region. The L/L genotype may reduce the risk of AD in the Caucasian population.

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Why is it important?

AD pathogenesis can be influenced by SLC6A4. However, the relationships among SLC6A4 polymorphisms, methylation rates, and the mRNA expression level in leukocytes in AD have not been examined.


Our results suggest that higher SLC6A4 mRNA expression levels in leukocytes of AD may be associated with apathy regardless of the SLC6A4 genotype and the methylation rates of the SLC6A4 promoter region. 5-HTT-LPR may play an important role in AD in the Caucasian population. Further studies are warranted to confirm these findings.

Dr Junichi Iga
Ehime University

Read the Original

This page is a summary of: Association Study and Meta-Analysis of Polymorphisms, Methylation Profiles, and Peripheral mRNA Expression of the Serotonin Transporter Gene in Patients with Alzheimer's Disease, Dementia and Geriatric Cognitive Disorders, January 2016, Karger Publishers,
DOI: 10.1159/000447324.
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