Alternative Polyadenylation: Another Foe in Cancer

What is it about?

Human transcriptome is complex. Individual genes have the potential to generate variants of the transcripts that can be regulated differently. these variants, when deregulated, can explain some of the functional alterations seen in disease states including cancer. This review focuses on a specific mechanism, alternative polyadenylation, that has the potential to change how an mRNA is translated.

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Why is it important?

deregulated alternative polyadenylation related changes can explain some cancer related gene activation or inactivation cases where no known mechanism has been described.