Survival of Del17p CLL Depends on Genomic Complexity and Somatic Mutation

What is it about?

CLL with 17p deletion represents the most challenging disease group, with poor overall survival, yet significant heterogeneity in survival. We hypothesized that the concurrent genomic landscape of del17p CLL would predict this heterogeneity in outcome, and therefore undertook to characterize the somatic mutation and copy number landscape in this subgroup of CLL, which has been under-represented in all prior sequencing studies. Our results demonstrate that subclonal rather than clonal mutation of the second TP53 allele and lack of genomic complexity of any type are characteristic of patients with longer overall survival, who may not require therapy for an extended period. These results have direct implications for clinical prognostication.

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