What is it about?
This work showed an increased infiltration of macrophages predominantly polarized to M2 in the kidneys of hypertensive animals, associated with high levels of YM1/Chi3l3 (91,89%), suggesting that YM1/Chi3l3 may be a biomarker of hypertensive nephropathy.
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Why is it important?
Our transgenic animals come from a hypertensive environment and exhibit overexpression of Angiotensinogen, but we cannot state that Ang II is the mediator of M2 macrophage polarization in the kidneys of our animal model, since other members of the RAAS may be involved. We showed for the first time that the lean hypertensive animals presented macrophage polarization to the M2 phenotype with high levels of YM1/Chi3l3, linked to renal damage and fibrosis. It suggests that YM1/Chi3l3 may serve as a new biomarker of hypertensive nephropathy.
Perspectives
Future studies are needed involving both YM1/Chi3l3 in mice and YKL-40 in humans at different time points to confirm whether reducing levels of these proteins may be beneficial in delaying the development of hypertensive nephropathy.
PAULA ANDREA MALVEIRA CAVALCANTE
Universidade Federal de Sao Paulo
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This page is a summary of: Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein, Mediators of Inflammation, July 2019, Hindawi Publishing Corporation,
DOI: 10.1155/2019/9086758.
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