Detection by Flow Cytometry of anti- DNA autoantibodies and immune complexes
What is it about?
A new method for the detection by flow cytometry of anti- DNA antibodies and of circulating immune complexes containing endogenous DNA is described.
Why is it important?
Autoantibodies to double-stranded DNA are the serological hallmark of systemic lupus erythematosus (SLE). When anti-DNA antibodies are neutralized by endogenous DNA and can no longer be detected by routine tests, the serologic diagnosis and the follow-up of relapses in patients with SLE is compromised. To overcome this obstacle, we propose an accessible solution: the detection of circulating DNA immune complexes by flow cytometry.
The following have contributed to this page: Dr. Mohamed Moumaris and Nisen ABUAF