What is it about?
A new method for the detection by flow cytometry of anti- DNA antibodies and of circulating immune complexes containing endogenous DNA is described.
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Why is it important?
Autoantibodies to double-stranded DNA are the serological hallmark of systemic lupus erythematosus (SLE). When anti-DNA antibodies are neutralized by endogenous DNA and can no longer be detected by routine tests, the serologic diagnosis and the follow-up of relapses in patients with SLE is compromised. To overcome this obstacle, we propose an accessible solution: the detection of circulating DNA immune complexes by flow cytometry.
Perspectives
The results of routine tests for the detection of anti-DNA autoantibodies do not correlate well. This could be due to the fact that lupus serum samples contain both anti-DNA autoantibodies, endogenous DNA and immune complexes. In the near future the tests should be designed and the results interpreted by integrating this data.
Nisen ABUAF
Faculté de Médecine, Sorbonne Université
Read the Original
This page is a summary of: Detection by Flow Cytometry of Anti-DNA Autoantibodies and Circulating DNA Immune Complexes in Lupus Erythematosus, Journal of Immunology Research, December 2019, Hindawi Publishing Corporation,
DOI: 10.1155/2019/6047085.
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