What is it about?
Atherosclerosis (AS) is a chronic disease with a typical pathological process of abnormal lipid metabolism. The medicine used to treat AS currently are mostly anti-inflammatory drugs. Hang-Lian Jie-Du Decoction (HLJDD), a classic prescription of TCM, was mainly depending on clearing away heat-toxin to intervene in the inflammatory disorder, the basic pathophysiological process of AS. It was essential to quantify the effective components accurately in HLJDD treated for AS. Therefore, we developed a UHPLC-MS/MS method for simultaneous determination of the active components in rat plasma. Then the method was used to quantify the active ingredients in AS rat plasma after oral three dosages of HLJDD.
Featured Image
Why is it important?
The existing research showed that HLJDD has a number of pharmacological effects and accumulating evidence has shown HLJDD’s efficacy on AS. Thus, it was essential to quantify the effective components accurately in HLJDD treated for AS. However, the reported pharmacokinetic studies of HLJDD failed to fully reflect the in vivo process of the compound due to its limited components in recent years. Moreover, to date, the multi-components of this effective and traditional formula in biological samples (e.g. AS rats) have been nearly rarely provided so far. Therefore, we developed a UHPLC-MS/MS method for simultaneous determination of the active components in rat plasma.
Read the Original
This page is a summary of: Simultaneous Determination of Seven Active Components in Rat Plasma by UHPLC-MS/MS and Application to a Quantitative Study after Oral Administration of Huang-Lian Jie-Du Decoction in High Fat-Induced Atherosclerosis Rats, International Journal of Analytical Chemistry, July 2019, Hindawi Publishing Corporation,
DOI: 10.1155/2019/5628160.
You can read the full text:
Contributors
The following have contributed to this page
