What is it about?
RNA sequencing was used to compare gene expression in upper, lower and marginal regions of a yeast colony and to follow changes in gene expression as the colony ages. Also, the upper and lower regions were divided into smaller subpopulations to reveal differences on a finer scale. Genes were grouped into functional categories (amino acid metabolism, transcription factors etc) to uncover metabolic reprogramming within parts of the colony over time and as cells differentiate.
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Why is it important?
1. The study reveals that lower cells can be considered as at least two sub-populations 2. Most reprogramming over time occurs in the upper cells 3. Upper and lower cells have different strategies for coping with age-related stresses 4. Mitochondria appear to be involved in differentiation/altered gene expression/metabolic reprogramming
Perspectives
The study generated a lot of data and the publications is an overview. We continue to mine the data for further insights into the processes that drive metabolic reprogramming as colonies age
Derek Wilkinson
Univerzita Karlova
Read the Original
This page is a summary of: Transcriptome Remodeling of Differentiated Cells during Chronological Ageing of Yeast Colonies: New Insights into Metabolic Differentiation, Oxidative Medicine and Cellular Longevity, January 2018, Hindawi Publishing Corporation,
DOI: 10.1155/2018/4932905.
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