Structural and Histochemical Alterations in the Aortic Valves of Elderly Patients: A Comparative Study of Aortic Stenosis, Aortic Regurgitation, and Normal Valves

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We showed that AS and AR valves have distinct structural differences related to the ageing process. AS valves display tissue remodelling upon damage and repair, whereas AR valves exhibit static chemical alterations due to ageing with slow collagen turnover. This study using both SAM and immunohistochemical methods revealed correlations between biomechanical and biochemical alterations that provides a novel tool for studying mechanism(s) associated with AV diseases.

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