What is it about?

Stingless bee honey supplementation to Swiss albino mice had positively shown an acutely significant improvement of spatial memory performance and it is possibly associated with the presence of phenylalanine in the stingless bee honey, which directly upregulates the BDNF and Itpr1 genes in the brain.

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Why is it important?

This study was conducted to evaluate the potential of stingless bee honey to improve learning and memory in mice, specifically via MWM behavior analysis as well as the BDNF and Itpr1 gene expression study. Collectively, the data in this study provides preliminary evidence suggesting that stingless bee honey treatment provides a positive role in improving memory performances in female mice.


The study provides behavioral evidence of the memory-enhancing effects of local-harvested stingless bee honey on mice, hence future studies are highly recommended to further confirm the underlying mechanism of this stingless bee honey in learning and memory.

Fairuz Nabila Zulkifli
Universiti Putra Malaysia

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This page is a summary of: Stingless Bee Honey Improves Spatial Memory in Mice, Probably Associated with Brain-Derived Neurotrophic Factor (BDNF) and Inositol 1,4,5-Triphosphate Receptor Type 1 (Itpr1) Genes, Evidence-based Complementary and Alternative Medicine, December 2019, Hindawi Publishing Corporation,
DOI: 10.1155/2019/8258307.
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