What is it about?
Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease, and chronic inflammation of the airways and lungs was considered to be an important pathological feature. Therefore, we have studied biomarkers (MMP-12, TIMP-4, NE) in COPDpatients and healthy subjects.The purpose of this study was to compare matrix metalloproteinase-12 (MMP-12), neutrophil elastase (NE), and tissue inhibitor of metalloproteinase-4 (TIMP-4) in peripheral blood of patients with chronic obstructive pulmonary disease (COPD) and controls. At the same time, MMP-12, NE, and TIMP-4 in exhaled breath condensate (EBC) were also evaluated.
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Why is it important?
Our study has detected MMP-12 and TIMP-4 in PBMCs， serum and exhaled breath condensate (EBC) of COPDpatients and healthy subjects. We found that the expression levels of MMP-12, NE, and TIMP-4 in PBMCs and serum were elevated in COPD patients. In PBMCs of COPD Patients, the mRNA expression level of NE may predict acute exacerbation, and MMP-12 mRNA expression level may be used to reflect the severity of airflow limitation.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also lead to COPD groups contacting me and ultimately to a greater involvement in COPD research.
Wendong Hao
Read the Original
This page is a summary of: Expressions of MMP-12, TIMP-4, and Neutrophil Elastase in PBMCs and Exhaled Breath Condensate in Patients with COPD and Their Relationships with Disease Severity and Acute Exacerbations, Journal of Immunology Research, April 2019, Hindawi Publishing Corporation,
DOI: 10.1155/2019/7142438.
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Contributors
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