What is it about?

Exploration of the active and natural anticancer compound 4,5-diCQA's effects of cell cycle arrest on prostate cancer cells.

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Why is it important?

Even though clinical management of cancer using chemotherapeutic agents has produced some success, there still exists a need to develop more effective treatment options. This necessitates the discovery and development of novel anticancer molecules. One of the current areas of investigation in this regard has been exploring the potential of active anticancer ingredients from natural products. These derivatives not only inhibit cancer cell proliferation, but also potentially have less side effects as compared to the currently used chemotherapeutics.


Our findings, for the first time, demonstrate the potent anticancer activity of 4,5-diCQA against prostate cancer cells via cell cycle arrest. This offers a potential novel treatment for cancer that should be further explored, as it is a natural compound that could offer less side-effects than current common treatments such as chemotherapy.

Olivia Lodise
Georgia Institute of Technology

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This page is a summary of: Inhibition of Prostate Cancer Cells by 4,5-Dicaffeoylquinic Acid through Cell Cycle Arrest, Prostate Cancer, May 2019, Hindawi Publishing Corporation,
DOI: 10.1155/2019/4520645.
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