What is it about?
Nrf2 (NF-E2-related factor 2) is a master regulator of cellular oxidative levels against environmental stresses. Nrf2 maintains the integrity of intestinal mucosal barrier by different way, such as: (1) NRF2 reduced intestinal mucosal injury by suppressing oxidative stress; (2) NRF2 decreased intestinal inflammation by inhibiting inflammatory pathway; (3) NRF2 affected intestinal tight junction proteins and apoptosis of cells to regulate intestinal permeability; (4) NRF2 affected T cell differentiation and functions；(5) The cross-regulation between the KEAP1-NRF2 pathway and autophagy controlled intestinal oxidative stress.
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Why is it important?
It is crucial to understand the mechanism of intestinal barriers for the development and treatment of intestinal disease.
Perspectives
Nrf2 becomes a potential target in the treatment of multiple intestinal diseases induced by mucosal barrier injury.
Zhiyong Wen
Gannan Medical University
Read the Original
This page is a summary of: A Protective Role of the NRF2-Keap1 Pathway in Maintaining Intestinal Barrier Function, Oxidative Medicine and Cellular Longevity, June 2019, Hindawi Publishing Corporation,
DOI: 10.1155/2019/1759149.
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