What is it about?
Hypoxia-induced pulmonary hypertension (HPH) is a severe condition associated with signifi-cant morbidity and mortality in people living at high altitude. Tsantan Sumtang, a traditional Ti-betan medicine, has been routinely used for the treatment of cardiopyretic disease, as well as sten-ocardia. Interestingly, our previous research found that Tsantan Sumtang improved HPH in rats maintaining in a hypobaric chamber. We performed a series of experiments to test the indexes of vasoconstriction and vascular remodeling, the key pathophysiological characteristics of HPH. Our results showed that Tsantan Sumtang relaxed noradrenaline (NE)-precontracted rat pulmonary ar-tery rings in a concentration-dependent manner in vitro. The PGI2-cAMP(Prostaglandin I2-Cyclic adenosine monophosphate)pathway, NO-cGMP (Nitric oxide-Cyclic guanosine monophosphate) pathway and the opening of K+ channels (inward rectifier K+ channels, large conductance Ca2+-activated K+ channels and voltage-dependent K+ channels) might play major roles in the vas-orelaxation effect. In vivo, the administration of Tsantan Sumtang resulted in a substantial decrease in the rat mean pulmonary artery pressure (mPAP) and the right ventricular hypertrophy index (RVHI). The reduction of thickness of small pulmonary arterial wall and the WT% (the ratio of the vascular wall thickness to the vascular diameter) were observed. The smooth muscle musculariza-tion of the arterials was alleviated by Tsantan Sumtang treatment at the same time. Tsantan Sum-tang also reduced remodeling of pulmonary arterioles by suppressing the expression of proliferat-ing cell nuclear antigen (PCNA), α-smooth muscle actin (α-SMA), cyclin D1 and cyclin-dependent kinase 4 (CDK4) through inhibition of p27Kip1 degradation. Therefore, Tsantan Sumtang could be applied as a preventative medication for HPH, which would be a new use for this traditional medi-cine.
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Why is it important?
Tsantan Sumtang could be applied as a preventative medication for HPH, which would be a new use for this traditional medicine
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This page is a summary of: Tsantan Sumtang Alleviates Chronic Hypoxia-Induced Pulmonary Hypertension by Inhibiting Proliferation of Pulmonary Vascular Cells, BioMed Research International, November 2018, Hindawi Publishing Corporation,
DOI: 10.1155/2018/9504158.
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