What is it about?

Genome-wide gene expression analysis using CodeLink™ bioarrays indicated that Glut1 and Glut10 were highly expressed in mouse cochlea. Semiquantitative RT-PCR and western blotting confirmed that Glut10 expression was high throughout the embryogenesis and postnatal development. Immunofluorescent staining showed that Glut10 protein was localized in the cuticular plate of the outer and inner cochlear hair cells and in the ampullary crest of the vestibular system. Based on these results, it was supposed that Glut10 may contribute to glucose transport from the endolymph to the hair cells across the cuticular plate.

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Why is it important?

Hair cells in the cochlea play a key role as true mechanoelectrical transducers. The present study provides new data regarding the expression of the transporter Glut10 in the hair cells of mouse cochlea and in the mouse ampullary crest. The data suggest that Glut10 is localized in the cuticular plate and may be important in facilitating its formation and consequently the hair cell movement that in turn affects the normal function of the organ of Corti.

Perspectives

We report here Glut10 was localized in the cuticular plate of the hair cells of the cochlea and vestibular system. It could be an indication for a functional role of hair cells in maintaining the supply of glucose in the cuticular plate. In addition, the present study suggests that Glut10 may play a role in hair cell movement, possibly via indirect modulation of the proteins involved in the cuticular plate formation (such as myosin, spectrin, fimbrin, and supervillin)

Dr Bei Chen
Zhengzhou University

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This page is a summary of: Localization of Glucose Transporter 10 to Hair Cells’ Cuticular Plate in the Mouse Inner Ear, BioMed Research International, June 2018, Hindawi Publishing Corporation, DOI: 10.1155/2018/7817453.
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