What is it about?
We examined the effects of RES on pro-survival (Akt-1, GSK-3β) and stress signaling (p38-MAPK, ERK 1/2, MKP-1) pathways, on oxidative stress (iNOS, COX-2 activity, ROS formation) and on left ventricular function, hypertrophy and fibrosis in a rat, isoproterenol (ISO) induced postinfarction heart failure model. RES treatment improved left ventricle function, decreased interstitial fibrosis, cardiac hypertrophy, and the level of plasma BNP induced by ISO treatment. ISO also increased the activation of P38-MAPK, ERK1/2, COX-2, iNOS and ROS formation and decreased the phosphorylation of Akt-1, GSK-3β and MKP-1, which were favorably influenced by RES.
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Why is it important?
According to our results regulation of these pathways may also contribute to the beneficial effects of RES in HF.
Perspectives
Cardioprotection with natural products
Eszter Szabados
Pecsi Tudomanyegyetem
Read the Original
This page is a summary of: Cardioprotective Effect of Resveratrol in a Postinfarction Heart Failure Model, Oxidative Medicine and Cellular Longevity, January 2017, Hindawi Publishing Corporation,
DOI: 10.1155/2017/6819281.
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