What is it about?
The increased chromosomal and oxidative DNA damage in patients with multi-nodular goiter may predict an increased risk of thyroid cancer in these patients.
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Why is it important?
MN frequency and plasma 8-OHdG levels may be markers of the carcinogenic potential of multi-nodular goiters and could be used for early detection of different cancer types, including thyroid cancer.
Perspectives
While the majority of thyroid nodules are benign, elevated chromosomal (MN frequency) and oxidative DNA damage (8-OHdG levels) are predictors of an increased risk of thyroid cancer and/or other types of cancer, in patients with multi-nodular goiter.
Increased DNA damage in patients with multi-nodular goiter Hamiyet Donmez Altuntas
Erciyes Universitesi
Read the Original
This page is a summary of: Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer, International Journal of Endocrinology, January 2017, Hindawi Publishing Corporation, DOI: 10.1155/2017/2907281.
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