What is it about?

Patients with cystic fibrosis have thick mucus secretions that prevent drugs from entering the lungs. This paper shows that heparin is able to break up the fibrous networks that constitute mucus.

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Why is it important?

Cystic fibrosis is a genetic disorder affecting many organs, most significantly the lungs, which become clogged with thick mucus secretions. Being able to clear this will allow inhaled drugs, including gene vectors that one day might provide the desired cure, to be delivered much more easily.


Free download of our key 2007 paper.

Dr James R Smith
University of Portsmouth

Read the Original

This page is a summary of: Unfractionated heparin reduces the elasticity of sputum from patients with cystic fibrosis, AJP Lung Cellular and Molecular Physiology, November 2007, American Physiological Society,
DOI: 10.1152/ajplung.00206.2007.
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