What is it about?
When blood flow into a heart chamber is increased, it causes the chamber to fill more. That distention makes the chamber adapt over time. This paper is about what happens to heart growth in the fetus when blood flow into the right side of the heart is increased.
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Why is it important?
How a fetus grows in utero determines their risk for heart disease in later life. The fetal heart grows rapidly, in ways that are fundamentally different than how the adult heart grows. It is important to understand how increased filling by blood affects fetal heart growth, because this may alter cardiac risk for life. Now we know that when filling of the right side of the fetal heart is increased, the heart muscle cells grow larger. This is a different response than when blood pressure is increased in the fetus, which also causes heart muscle cells to make more of themselves and to mature.
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This page is a summary of: Right ventricular remodeling in response to volume overload in fetal sheep, AJP Heart and Circulatory Physiology, May 2019, American Physiological Society,
DOI: 10.1152/ajpheart.00439.2018.
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