What is it about?
This review article summarizes the role of metabolic receptor families (succinate and alpha-ketoglutarate receptors, and purinergic and olfactory receptors) in the regulation of various renal and vascular functions.
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Why is it important?
The review emphasizes the emerging role and importance of metabolic intermediates in renal and vascular regulation acting in a non-traditional way, as signaling molecules via their receptors.
Perspectives
This article reviews only three metabolic receptor families that have been recently identified to play important roles in renal and vascular physiology. However, this is only the beginning, and many more metabolic receptors and their ligands are expected to be uncovered in the future, shedding more light on the direct metabolic control of critically important organ functions.
Professor Janos Peti-Peterdi
University of Southern California
Read the Original
This page is a summary of: Regulation of Vascular and Renal Function by Metabolite Receptors*, Annual Review of Physiology, February 2016, Annual Reviews,
DOI: 10.1146/annurev-physiol-021115-105403.
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