What is it about?
This article describes a combinatorial method for writing digital data into DNA molecules. It demonstrates the method by writing the Complete Works of Shakespeare (about 1 million words) into DNA molecules. The article demonstrates DNA computing at a large scale by showing how to perform word search on the written text using chemistry. Overall, this article shows that DNA computing has matured and is scalable enough to build real-world applications.
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Why is it important?
This is the first time ever that DNA computing has been shown to work at scale. The article demonstrates the writing of ~1 million words of text into DNA molecules. It shows how this text can be searched using DNA chemistry. The demonstration achieved perfect recall and high precision. All previous DNA computing demonstrations were at a smaller scale or exquisitely designed for a specific application. This is the first time that a commercially available platform has been described and demonstrated. The platform is scalable and capable of supporting many different types of applications.
Perspectives
DNA computing can achieve massive parallelism and energy efficiency unlike any other platform, and this is the only DNA computing platform likely to scale to real-world use cases.
Swapnil Bhatia
Catalog Technologies Inc.
Read the Original
This page is a summary of: Demonstration of a Scalable DNA Computing Platform: Writing and Selection, ACM Journal on Emerging Technologies in Computing Systems, June 2025, ACM (Association for Computing Machinery),
DOI: 10.1145/3744562.
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