Computer Pharmacological Analysis of Sanfeijie Pills

What is it about?

Sanfeijie Pills (SP) is one popular traditional Chinese medicine pills sold in some e-commerce platform, which has the better effect on pulmonary sarcoidosis (PS). However, its inner function mechanism thereof has not been clarified. For uncovering the mystery of its pharmacology, this study used the means of bioinformatics to research its principle of resolving hard lump. Thesis ideas are as below: HIT 2.0 database was used to get the ingredients of Sanfeijie pills; SwissADME network platform was used to carry on ingredients screening for drug like properties; the targets of ingredients passed the screening also originated from HIT database; the target genes associated with disease of PS originated from Genecards database; this study used Venn diagrams to obtain the intersection between drug targets and disease targets, that is, the effective target; the STRING platform served as generating the protein-protein interaction data; the enrichment analysis of these targets was conducted on the network platform Metascape; the software Cytoscape was used to derive biological network diagrams.

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Why is it important?

Our analysis proposed that the core therapy targets were TP53, AKT1, STAT3, TNF, SRC, IL6, JUN, CTNNB1, NFKB1, EP300, ESR1 and BCL2.

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