Glutathione effectively modulates the metabolism of cisplatin

What is it about?

By employing a metallomics method we show that the addition of glutathione to blood plasma either before or after cisplatin changes its metabolism. The detection of a new platinum-sulfur complex in plasma implies that its formation is directly involved in the process by which glutathione protects mammals from the cisplatin-induced toxicity.

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Why is it important?

These finding are important because they identify another small molecular sulfur compound that can be employed to modulate the metabolism of cisplatin in a desireable way to reduce the toxic side effects of cisplatin.