Orthobiologics for management of osteoarthritis

What is it about?

Orthobiologics, including platelet rich plasma, bone marrow aspirate concentrate, and adipose-derived mesenchymal stem cells, have become a growing field of research for treatment of osteoarthritis. The hope is that these biologic modalities will alter the natural progressing of the disease affording patients pain relief and restoration of functionality. To date, the evidence has not demonstrated consistent, clear benefits of orthobiologics. Further investigation is ongoing to identify optimal indications, preparations, compositions, safety profiles, and clinical outcomes.

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Why is it important?

Osteoarthritis is a leading cause of disability and pain in patients worldwide. There are numerous management options available to patients for management including anti-inflammatory medications, injection therapies, arthroscopy, and arthroplasty. To date, no treatment options have been shown to reliably and consistently halt or reverse disease progression. Orthobiologics have emerged as promising therapeutic options with the hopes of altering disease progression. Data is limited at this time in human studies but animal models are encouraging.