Coronary slow flow is associated with a worse clinical outcome in patients with Takotsubo syndrome

Rocco A Montone, Leonarda Galiuto, Maria Chiara Meucci, Marco Giuseppe Del Buono, Federico Vergni, Massimiliano Camilli, Tommaso Sanna, Daniela Pedicino, Antonino Buffon, Domenico D'Amario, Luca Giraldi, Carlo Trani, Giovanna Liuzzo, Antonio G Rebuzzi, Giampaolo Niccoli, Filippo Crea
  • Heart, January 2020, BMJ
  • DOI: 10.1136/heartjnl-2019-315909

What is it about?

Our study demonstrated that Takotsubo patients presenting a delayed coronary flow, the so-called coronary slow flow (CSF), at coronary angiography have a worse clinical presentation at admission with a higher rate of intrahospital complications. Moreover, Takotsubo patients with CSF had also a poor long-term clinical outcome due to a higher rate of death from any causes, suggesting the potential role of CSF, a simple angiographic sign easily detectable in every hospital with a catheterization laboratory, for prognosis stratification of patients with Takotsubo syndrome.
Of importance, our study also demonstrated that higher mortality in Takotsubo patients with CSF was mostly driven by non-cardiac causes, thus suggesting the intriguing hypothesis that severe functional alterations may represent, in this subset of patients, an epiphenomenon probably triggered by an underlying acute or chronic disease (i.e. neurologic, neoplastic, infective), that in turn affects the prognosis and needs to be further investigated

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The following have contributed to this page: Giampaolo Niccoli