PWE-105 Clinical efficacy of the combination of propofol and ketamine (ketofol) for deep sedation for colonoscopy

S Amornyotin, W Chalayonnawin, S Kongphlay
  • Gut, May 2012, BMJ
  • DOI: 10.1136/gutjnl-2012-302514d.105

Clinical efficacy of propofol and ketamine (ketofol) for deep sedation for colonoscopy

What is it about?

A combination of propofol and ketamine is usually used to achieve sedation and analgesia during colonoscopy. Few studies have compared their efficacy. The aim of this study was to compare and evaluate the clinical efficacy of the combination of propofol and ketamine (ketofol) vs propofol alone when each regimen is used as sedative agents for colonoscopy.

Why is it important?

All endoscopies were completely successfully. Mean total dose of propofol in group PK and PN was 6.98 (2.90) mg/hg/h and 7.73 (3.45) mg/kg/h, respectively (p¼0.413). Mean total dose of ketamine in group PK was 1.49 (0.61) mg/hg/h. There were no significant differences in patient tolerance, discomfort during insertion, patient and endoscopist satisfaction, haemodynamic responses, procedural pain, recovery time and recovery score. Overall, cardiovascular and respiratory adverse events were not significantly different between the two groups. These adverse events were transient and easily treated with no sequelae.


Somchai Amornyotin
Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University

IVS in both regimens provided effective and safe for colonoscopy. Adverse events were relatively high in both groups. However, these adverse events were mild and transient. No serious adverse events were observed.

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The following have contributed to this page: Somchai Amornyotin