What is it about?
curcumin may have multiple targets in liver including activation of PPARgamma in cholangiocytes and inhibition of ERK1/2 signalling in MFBs, thereby modulating several central cellular events in a model of cholangiopathy.
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Why is it important?
Targeting these pathways may be a promising therapeutic approach to cholangiopathies.
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This page is a summary of: Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation, Gut, March 2010, BMJ,
DOI: 10.1136/gut.2009.186528.
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