What is it about?
This study aims to establish and assess a novel model to calculate HVPG based on biofluid mechanics. This is a prospective, randomised, non-controlled, multicentre trial. A total of 248 patients will be recruited in this study, and each patient will undergo CT, blood tests, Doppler ultrasound and HVPG measurement. The study consists of two independent and consecutive cohorts: original cohort (124 patients) and validation cohort (124 patients). The researchers will establish and improve the HVPG using biofluid mechanics (HVPGBFM) model in the original cohort and assess the model in the validation cohort.
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Why is it important?
Portal hypertension is a severe disease with a poor outcome. Hepatic venous pressure gradient (HVPG), the current gold standard to detect portal hypertension, is only available in few hospitals due to its invasiveness and technical difficulty. If this biofluid mechanics-based model proves credible, it will be easier for physicians to monitor patients’ HVPG values in the future, which will be helpful for diagnosing and evaluating the severity of cirrhosis and portal hypertension.
Perspectives
We decided to publish the study protocol in full because this can increase transparency and exposure of our study and enable more collaboration hopefully. We welcome all kinds of cooperation. Please contact: lin_jiayun@outlook.com Thank you.
Jiayun Lin
Read the Original
This page is a summary of: Establishment and assessment of the hepatic venous pressure gradient using biofluid mechanics (HVPGBFM): protocol for a prospective, randomised, non-controlled, multicentre study, BMJ Open, December 2019, BMJ,
DOI: 10.1136/bmjopen-2018-028518.
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