Effects of tolvaptan add-on therapy in patients with acute heart failure: meta-analysis on randomised controlled trials

What is it about?

Increased the Worsening Renal Function of tolvaptan in patients with acute decompensated heart failure. Tolvaptan was not reducing the incidence of Worsening Renal Function or short-term all-cause mortality , however, it decreases the body weight while increases the sodium level . Only 7 randomized controlled studies were included, however, some studies have limitations. Lack of unified standards for the dosage, the tolvaptan use duration and follow-up time, which may affect the clinical outcomes. Only English language studies included.

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