Deviation from intention to treat analysis is a source of bias

What is it about?

The publication of randomised trials that report deviations from the intention to treat approach or report a modified approach has become more common in the medical literature. Reporting of deviations is significantly associated with post-randomisation exclusions, funding, and authors’ conflicts of interest

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Why is it important?

Our results showed that randomised trials that deviate from the intention to treat approach overestimate the treatment effect of meta-analyses compared with those trials that report a standard approach