Exogenous and endogenous endophthalmitis caused by Sporothrix

What is it about?

Sporotrichosis is an implantation mycosis caused by Sporothrix, which occasionally can result in exogenous or endogenous infection. This systematic review showed anterior uveitis to be more common in exogenous endophthalmitis and posterior uveitis more common in endogenous endophthalmitis, especially in HIV-infected patients and those from hyperendemic areas.

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Why is it important?

Sporothrix infection should be included in the differential diagnosis for ocular inflammation, regardless of the presence or absence of autoimmune comorbidities and whether the patient resides in an endemic area or not. Ophthalmologists should also consider intravitreal and systemic antifungal therapy in cases of exogenous or endogenous endophthalmitis caused by Sporothrix.