Stevens-Johnson syndrome/toxic epidermal necrolysis: treatment with low-dose corticosteroids, vitamin C and thiamine

What is it about?

We present the case of a 33-year-old female who was transferred to our hospital with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) overlap syndrome secondary to ibuprofen exposure. She was treated with supportive care as well as “low dose” intravenous hydrocortisone, ascorbic acid (vitamin C) and thiamine (HAT therapy). After starting this therapy, the patient demonstrated a dramatic response with rapid improvement of her cutaneous and mucosal lesions. This simple, cheap and safe intervention holds much promise for the treatment of this potentially fatal disease.

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