Non-infectious aortic and mitral valve vegetations in a patient with eosinophilic granulomatosis with polyangiitis

What is it about?

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare form of vasculitis characterized by atopic manifestations, inflammation of small to medium-sized arteries and veins, hyper-eosinophilia, and tissue infiltration with eosinophils, Cardiac complications occur most commonly in the absence of anti-neutrophil cytoplasmic antibodies (ANCA). Cardiac complications include coronary arteritis (rare), pericarditis, myocarditis, endocardial fibrosis (Loeffler’s endocarditis), and intracavitary thrombosis of the left or right ventricle. This is the first reported case of large non-infectious valvular vegetations associated with EGPA.

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