What is it about?
Nonalcoholic fatty liver disease (NAFLD) represents a major burden on health systems around the world. Here, we analyzed the intra-hepatic metataxonomic signature of NAFLD patients with varying degrees of disease pathology. Overall, we found that the liver tissue contains a diverse repertoire of bacterial DNA. Across major host phenotypic differences—from moderate to severe obesity—, we identified distinctive liver microbial DNA patterns associated with key histological features such as the disease severity, liver inflammation, and fibrosis. The strongest severe disease-associated imbalance in bacterial DNA was highly linked to obesity. Whereas overabundance of Proteobacteria (Alpha or Gamma) was predominantly seen in liver specimens of non-morbidly obese patients, an overrepresentation of Peptostreptococcus, Verrucomicrobia, Actinobacteria, and Proteobacteria derived-DNA was more frequently observed in livers of morbidly obese patients. Notably, decreased amounts of bacterial DNA from the Lachnospiraceae family were associated with more severe histological features. Our study suggests that therapeutic options, including probiotic selection, should be precisely defined according to specific clinical scenarios, including features of the host phenome. The presence of lipopolysaccharide reinforces the concept.
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Why is it important?
The liver bacterial DNA signature may explain differences in NAFLD pathogenic mechanisms, as well as the physiological functions of the host.
Read the Original
This page is a summary of: Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease, Gut, January 2020, BMJ, DOI: 10.1136/gutjnl-2019-318811.
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