Non-coding RNAs in GI cancers: from cancer hallmarks to clinical utility

What is it about?

In this review we present the mechanistic function of microRNAs, long non-coding RNAs and circular RNAs (most studied species of non-coding RNAs) in each of the hallmarks of GI cancer and discuss their potential roles as diagnostic tools and therapeutic targets. Additionally, we focus on some “heretical” concepts that can help in the development of clinical applications related to ncRNAs, including using phylogenetic conservation or pyknons to discover new non-coding transcripts, targeting human-specific transcripts which are expressed solely in the malignant cell and using ncRNAs to increase the efficiency of immunotherapy.

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