What is it about?
Pancreatic cancer is one of the most lethal cancers, with a 5-year survival rate of less than 5%. Currently, tumours are graded using a three-tiered pathological system ranging from well, moderate to poor. However, the vast majority of tumours are classified as moderate, which gives little clinical information to physicians about how best to treat these patients. We propose a revised classification system that stratifies tumours into two groups, based on the presence </> 40% of aberrant, destructive patterns. These two groups correlate with known molecular subtypes, classical (<40%) and basal (>40%), respectively, which are associated with clinical outcome.
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Why is it important?
Matching tumour tissue patterns to their molecular make-up has yielded a new way to group pancreatic tumours, which will help clinicians better tailor treatments to patients, with the aim of improving survival. Molecular profiling, while making significant advancements to cancer therapy, is both expensive and requires specialized equipment. Now with this new, easily applicable pathology classification, which is able to provide similar information using standard pathology stains with a rapid turnaround time.
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This page is a summary of: Morphological classification of pancreatic ductal adenocarcinoma that predicts molecular subtypes and correlates with clinical outcome, Gut, June 2019, BMJ, DOI: 10.1136/gutjnl-2019-318217.
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