What is it about?
This paper describes the biochemical role of a protein Nse2. The protein is required for the attachment of a small protein modifier (SUMO) to Smc5, a protein required for DNA repair and replication.
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Why is it important?
This was the first identification of a SUMO ligase associated wit the Smc5/ complex.
Perspectives
This was the first identification of a SUMO ligase associated wit the Smc5/ complex. It follows on from a paper published back to back with it, from our labs on the composition of the Smc5/6 complex.
Dr Felicity Z Watts
University of Sussex
Read the Original
This page is a summary of: Nse2, a Component of the Smc5-6 Complex, Is a SUMO Ligase Required for the Response to DNA Damage, Molecular and Cellular Biology, January 2005, ASM Journals,
DOI: 10.1128/mcb.25.1.185-196.2005.
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