What is it about?
This paper describes the components of the Smc5/6 complex: these are two large coiled coil protein - Smc5 and Smc6, as well as some smaller non-Smc proteins, Nse1-4.
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Why is it important?
The Smc5/6 complex is essential for cell viability. It is required for response to DNA damaging agents and for some aspect of DNA replication.
Perspectives
The Smc5/6 complex resembles the cohesion and condensing complexes. However, unlike these two complexes whose biochemical and cellular functions have been well characterized, the function of the Smc5/6 complex is less well understood.
Dr Felicity Z Watts
University of Sussex
Read the Original
This page is a summary of: Composition and Architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) Complex, Molecular and Cellular Biology, January 2005, ASM Journals,
DOI: 10.1128/mcb.25.1.172-184.2005.
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Resources
The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair
Initial cloning of the S. pombe ad18 gene
Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damag
Important paper on the characterisation of a SUMO ligase associated with the Smc5/6 complex.
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