What is it about?
Ubiquitous micro-calpain protease interacts with the deubiquitinating enzyme USP1. In vitro calpain can cleave and degrade USP1. On the opposite, in the living cell, calpain prevents APC/cdh1-dependent proteasome mediated degradation of USP1. Therefore calpain, stabilizing USP1, contributes to preserve genome integrity.
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Perspectives
Since we found that calpain inhibition is coupled to USP1 instability, we may speculate that calpain inhibitors may represent convenient drugs for specific cancers where the calpain/ Cdk5/cdh1/USP1 axis is active.
Dr Francesca Demarchi
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This page is a summary of: CAPNS1 Regulates USP1 Stability and Maintenance of Genome Integrity, Molecular and Cellular Biology, April 2013, ASM Journals,
DOI: 10.1128/mcb.01406-12.
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