What is it about?
Mutations of ATRX, a chromatin remodeler, have been associated in tumor cells with activation of an alternative pathway of telomere maintenance that is independent of telomerase. Here, we show that genetically inactivating ATRX in cultured tumor cells leads to a decrease in the level of cohesin on telomeric chromatin as well as a diminution in transcription of telomeric DNA into TERRA.
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Why is it important?
By implicating cohesin in pathways that are associated with a mutation in ATRX, we provide a new lead to try and understand why the cancer types functioning independently of telomerase (using the ALT pathway) are linked to this mutation.
Perspectives
The perspective concerning the role of ATRX in telomere maintenance is to find the probable existing partners that link the mutation in ATRX and the down regulation of both telomeric cohesin and TERRA.
Mr Michel Charbonneau
CNRS UMR 7292; University of Tours
Read the Original
This page is a summary of: Genetic Inactivation ofATRXLeads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells, Molecular and Cellular Biology, June 2015, ASM Journals,
DOI: 10.1128/mcb.01317-14.
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